N-terminal Residues of Plasmatocyte-spreading Peptide Possess Specific Determinants Required for Biological Activity
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چکیده
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Synthesis and biological activity of N-substituted-tetrahydro-γ-carbolines containing peptide residues
The synthesis of novel peptide conjugates of N-substituted-tetrahydro-γ-carbolines has been performed using the sequence of the Ugi multicomponent reaction and Cu(I)-catalyzed click chemistry. The effect of obtained γ-carboline-peptide conjugates on the rat liver mitochondria was evaluated. It was found that all compounds in the concentration of 30 µM did onot induce depolarization of mitochond...
متن کاملPlasmatocyte-spreading peptide (PSP) plays a central role in insect cellular immune defenses against bacterial infection.
Insect hemocytes (blood cells) are a central part of the insect's cellular response to bacterial pathogens, and these specialist cells can both recognize and engulf bacteria. During this process, hemocytes undergo poorly characterized changes in adhesiveness. Previously, a peptide termed plasmatocyte-spreading peptide (PSP), which induces the adhesion and spreading of plasmatocytes on foreign s...
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Calcitonin-family receptors comprise calcitonin receptor-like receptor (CL) or calcitonin receptor and receptor activity-modifying protein (RAMP) pairings. Calcitonin gene-related peptide (CGRP) receptors are CL/RAMP1, whereas adrenomedullin (AM) receptors are CL/RAMP2 (AM1 receptor) or CL/RAMP3 (AM2 receptor). Amylin (Amy) receptors are RAMP hetero-oligomers with the calcitonin receptor (AMY1,...
متن کاملEvaluation of Serum Levels of N-terminal Pro Brain Natriuretic Peptide and Atrial Natriuretic Peptide in Neonates with Respiratory Distress
Background: Acute respiratory distress (ARD) is a critical respiratory failure due to lung injury of neonates leading to the clinical appearance of poor lung compliance. The aimed of the study was to evaluate the diagnostic values in differentiating respiratory from heart diseases with using of N-terminal pro brain natriuretic peptide (NT-pro BNP) and Atrial natriuretic peptide(ANP) in neonates...
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Levvy, G. A. (1948). Biochem. J. 42, 2. Levvy, G. A. (1952). Biochem. J. 52, 464. Levvy, G. A. (1954). Biochem. J. 58, 462. Levvy, G. A. & Marsh, C. A. (1952). Biochem. J. 52, 690. Lohmar, R., Dimler, R. J., Moore, S. & Link, K. P. (1942). J. biol. Chem. 143, 551. Marsh, C. A. (1952). J. chem. Soc. p. 1578. Marsh, C. A. (1954). Biochem. J. 58, 609. Marsh, C. A., Alexander, F. & Levvy, G. A. (19...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2001
ISSN: 0021-9258
DOI: 10.1074/jbc.m105235200